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Role of NADPH Oxidase and GSH in Cystic Fibrosis |
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| รหัสดีโอไอ | |
| Creator | นุชจิรา พงศ์นิมิตรประเสริฐ |
| Title | Role of NADPH Oxidase and GSH in Cystic Fibrosis |
| Publisher | คณะเภสัชศาสตร์ ม.ศิลปากร/ โรงพิมพ์มิตรเจริญการพิมพ์ นครปฐม |
| Publication Year | 2553 |
| Journal Title | ไทยไภษัชยนิพนธ์ |
| Journal Vol. | 5 |
| Journal No. | 1(มค-ธค) |
| Page no. | 60-72 |
| Keyword | cystic fibrosis,NADPH oxidases, GSH |
| ISSN | 1686-9540 |
| Abstract | Cystic fibrosis (CF ), an autosomal recessive disorder that is resulted from mutations in the cystic fibrosis transmembrance conductance regulator (CFTR) gene,leading to a reduction in apical membrance cholride transport. The mechanism of CF has been the subject of debate that it may be associated with nicotinamide adenine dinucleotide phosphate ( NADPH) oxidases and depletion of glutathione (GSH). NADPH oxidases are proteins that transfer electrons across biological membrance,resulting in the reactive oxygen species (ROS) production and play a key role in host defenses in CF . Depletion of GSH in CF because of defect in CFTR may alter GSH availability by modulating epithelial GSH transfer, and then contributes to an imbalance in the antioxidant defense and results in oxidative stress. These effects can make cells damage from ROS. |
