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Safety and efficacy assessment of skin gelcontaining nanoemulsion of Phyllanthus emblica extract:A randomized, double-blind, placebo-controlled study |
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| รหัสดีโอไอ | |
| Creator | 1. Bungorn Sripanidkulchai 2. Rungsiri Chaiittianan 3. Khaetthareeya Suttanut |
| Title | Safety and efficacy assessment of skin gelcontaining nanoemulsion of Phyllanthus emblica extract:A randomized, double-blind, placebo-controlled study |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 2 |
| Page no. | 305-313 |
| Keyword | skin whitening, emblica, nanoemulsion, randomized double-blind, clinical trials, melanin index |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | A skin gel containing a nanoemulsion of Phyllanthus emblica branch extract (emblica nanogel) was tested for its safetyand efficacy in a randomized, double-blind, placebo-controlled clinical trial. The patch skin irritation test showed that neither theemblica nanogel nor the placebo nanogel caused skin erythema. The subjects receiving emblica nanogel had a significantly lowermelanin index of the cheek at weeks 2, 4, 6, and 8, of the forehead at weeks 4, 6, and 8, and of the forearm at week 8 compared tothe placebo group. Skin elasticity was observed to increase for the cheek at week 4, forehead at week 6, and there was no changefor the forearm. The levels of skin moisture and erythema of the subjects were not significantly different from the base linelevels. In conclusion, the application of emblica nanogel resulted in significant skin whitening during the 8 weeks of application. |
