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Effect of lemongrass gel against Candida albicans in rat modelof oral candidiasis |
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| รหัสดีโอไอ | |
| Creator | 1. Suwimol Taweechaisupapong 2. Thidarut Boonmars 3. Panitta Satthanakul 4. Visarut Chatchanayuenyong 5. Suwara Nitinon 6. Unthika Soodtoetong 7. Watcharapon Thipsongkroh 8. Watcharee Khunkitti |
| Title | Effect of lemongrass gel against Candida albicans in rat modelof oral candidiasis |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 2 |
| Page no. | 299-304 |
| Keyword | candidiasis, Candida albicans, lemongrass gel, rat model |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Candidiasis is the most prevalent fungal infection found in the oral cavity. Current interventions for oral fungal infections are not very successful and require a long treatment period. This research aims to study the in vitro and in vivo effects oflemongrass oil on Candida albicans. The antifungal activities of lemongrass oil towards C. albicans were determined by brothmicrodilution and time-kill assay. A lemongrass gel was formulated and its antifungal potential was evaluated in the rat model.The results from the in vitro study revealed that lemongrass oil possesses potent antifungal activity. In the in vivo study, 15Sprague-Dawley rats were divided into 3 groups and treated with gel base, lemongrass gel, and Daktarin? gel. After 2 weeks, thequantity of C. albicans in the oral tissues of lemongrass gel- and Daktarin?-treated rats was significantly lower than the gel basegroup (P<0.05). The C. albicans colony-forming units of the lemongrass-treated rats was insignificantly different from the ratstreated with Daktarin? gel. The data indicated that lemongrass and Daktarin? gel achieved comparable efficacy against C.albicans in a rat model which suggests the potential use of lemongrass gel for oral candidiasis. |
