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Anti-obesity potential of glutinous black rice bran extract:Anti-adipogenesis and lipolysis inductionin 3T3-L1 adipocyte model |
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| รหัสดีโอไอ | |
| Creator | 1. Warathorn Chumchoochart 2. Khaetthareeya Sutthanut |
| Title | Anti-obesity potential of glutinous black rice bran extract:Anti-adipogenesis and lipolysis inductionin 3T3-L1 adipocyte model |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 2 |
| Page no. | 284-291 |
| Keyword | anti-obesity, anti-adipogenesis, lipolysis induction, antioxidation, glutinous black rice bran |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | An ethanolic glutinous black rice bran extract (RBE) was prepared and used in the experiments to determine thephenolic and flavonoid contents, antioxidation using DPPH and TBARS assay, anti-adipogenesis, and lipolysis induction in a3T3-L1 pre-adipocyte model to discover its anti-obesity potential. The results showed that RBE was composed of phenolics,flavonoids, and anthocyanins and showed antioxidative activities (8.58?0.14 mg Vit C eq/g extract and 6.06?0.49 mg BHT eq/gextract). Interestingly, its anti-obesity potential was demonstrated in the interruption of the adipocyte life cycle, i.e. a significantanti-adipogenesis effect in the reduction of lipid accumulation (50.86?3.26 to 97.06?8.09% of the negative control, and triglyceride content in 3T3-L1 pre-adipocytes (36.89?2.08 to 90.56?0.67% of the negative control), and lipolysis induction (relativeglycerol content 117.62?1.44 and 163.72?10.18% of control). Therefore, implementation into obesity therapy requires furtherresearch. |
