|
Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging in Peripheral Zone Prostate Cancer Detection |
|---|---|
| รหัสดีโอไอ | |
| Creator | Pornphan Wibulpolprasert |
| Title | Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging in Peripheral Zone Prostate Cancer Detection |
| Contributor | Sasiprapa Rongthong, Sith Phongkitkarun, Panas Chalermsanyakorn |
| Publisher | Faculty of Medicine Ramathibodi Hospital, Mahidol University |
| Publication Year | 2561 |
| Journal Title | Ramathibodi Medical Journal |
| Journal Vol. | 41 |
| Journal No. | 3 |
| Page no. | 001-012 |
| Keyword | Prostate cancer, Peripheral zone, Multiparametric MRI, Diagnostic accuracy |
| URL Website | https://www.tci-thaijo.org/index.php/ramajournal |
| Website title | Ramathibodi Medical Journal |
| ISSN | 0125-3611 |
| Abstract | Background: Multiparametric magnetic resonance imaging (mp-MRI) has emerged as the best noninvasive imaging modality for prostate cancer detection, grading, staging, and targeted biopsy guidance. Validate performance of mp-MRI for peripheral zone prostate cancer detection is important for clinical implication.Objective: To determine the accuracy of T2-weighted (T2W) imaging, diffusion-weighted imaging (DWI), three dimensional (3D) magnetic resonance spectroscopic (MRS) and dynamic contrast-enhanced imaging (DCE) in peripheral zone prostate cancer detection.Methods: The retrospective study included 38 patients who has undergone pre-operative endorectal MRI from March 2006, to March 2010. The correlation of T2W, DWI, MRS and DCE in differentiation between tumor and non-tumor areas were analyzed by using Pearson's chi-square test or Fisher's exact test. The receiver operating characteristic (ROC) analysis was use to evaluate the distinguishing ability of T2W, DWI, MRS, DCE, and the combinations in tumor detection.Results: In 76 lesions from 38 patients, the area under the ROC curve (AUC) for tumor detection was 0.86 (T2W), 0.86 (DWI), 0.95 (MRS), and 0.61 (DCE). Combination of T2W+DWI, T2W+MRS, T2W+DCE achieved an AUC of 0.86, 0.92, and 0.80, respectively. There is no statistically significant difference in AUC between combination of T2W+DWI (0.86), and combination of T2W+DWI+DCE (0.82), T2W+DWI+MRS (0.81), or T2W+DWI+MRS+DCE (0.78).Conclusions: DWI is the most useful complementary sequence to conventional anatomical T2W imaging for prostate cancer foci identification. The 3D-MRS and DCE images may be use as confirmation tools in peripheral zone prostate cancer detection. |
