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Synthesis and antimicrobial activity screening of 2-(2-fluorophenylimino)-5-arylidenethiazolidin-4-one derivatives |
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| รหัสดีโอไอ | |
| Creator | 1. D.T. Pham 2. T.M.H. Vo 3. P. Truong 4. P.T. Ho 5. N. Khorana |
| Title | Synthesis and antimicrobial activity screening of 2-(2-fluorophenylimino)-5-arylidenethiazolidin-4-one derivatives |
| Publisher | Faculty of Pharmacy, Mahidol University |
| Publication Year | 2559 |
| Journal Title | Mahidol University Journal of Pharmaceutical Sciences |
| Journal Vol. | 43 |
| Journal No. | 1 |
| Page no. | 45-53 |
| Keyword | thiazolidin-4-one, synthesis, antibacterial, antifungal, MRSA |
| Abstract | Twelve derivatives of 2-(2-fluorophenylimino)-5-arylidenethiazolidin-4-one (F1-F12) were synthesized using 2-fluoroaniline as a reactant through 3-step process including acylation reaction, cyclisation reaction and aldol condensation reaction. All synthesized compounds were elucidated the structure by infrared (IR), ultraviolet (UV), nuclear magnetic resonance (NMR) and mass spectra (MS). None of the synthesized compounds inhibited Candida albicans or Aspergillus niger. Compounds F4 and F8 showed antibacterial activity on Staphylococcus aureus with MIC ฒ 64 _g/ml and methicillin-resistant Staphylococcus aureus (MRSA) with MIC ฒ 64 _g/ml. These compounds have potential for further investigation and modification to become potential therapeutic drugs in the future. |
