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Evaluation of antidepressant like activity in Amaranthus caudatus |
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| รหัสดีโอไอ | |
| Creator | 1. B.S. Ashok Kumar 2. K. Lakshman 3. Saleemullakhan 4. C. Velmurugan 5. E.R. Vishwanath 6. S. Gopisetty |
| Title | Evaluation of antidepressant like activity in Amaranthus caudatus |
| Publisher | Faculty of Pharmacy, Mahidol University |
| Publication Year | 2558 |
| Journal Title | Mahidol University Journal of Pharmaceutical Sciences |
| Journal Vol. | 42 |
| Journal No. | 1 |
| Page no. | 23-28 |
| Keyword | Amaranthus caudatus,Antidepressant activity,Tail suspension test,Forced swimming test |
| Abstract | Depression is a chronic illness that affects mental stability, personal and social relations. Herbal drugs possess least side effects compared to synthetic medicines. Amaranthus caudatus belongs to family Amaranthaceae. Antidepressant activity of methanolic extract of whole plant of Amaranthus caudatus (MEAC) was investigated by using forced swimming test (FST) and tail suspension test (TST) models. Animals are divided into five groups, group 1 receives normal saline, group 2 and 3 receives escitalopram (4 mg/kg) and imipramine (4 mg/kg) and group 4 and 5 receives MEAC (100 and 200 mg/kg) dose respectively. Preliminary phytochemical analysis showed the presence of phenolic compounds, steroids, alkaloids, flavonoids, saponins and amino acids in methanol extract of A. caudatus. |
