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Dexamethasone preconditioning may improve isoflurane- induced memory impairment by stabilising blood-brain barrier |
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| รหัสดีโอไอ | |
| Creator | Xiaoping Gu |
| Title | Dexamethasone preconditioning may improve isoflurane- induced memory impairment by stabilising blood-brain barrier |
| Contributor | Xueming Shao, Xiuxiu Li, Minhui Xu, Fangxia Xu, Peng Zhang, Zhengliang Ma, Tianjiao Xia |
| Publisher | Maejo University |
| Publication Year | 2567 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 18 |
| Journal No. | 1 |
| Page no. | 27 |
| Keyword | dexamethasone preconditioning, isoflurane anesthesia, blood-brain barrier stability, perioperative neurocognitive disorder |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | Perioperative neurocognitive disorder (PND) is a serious neurological complication that often follows surgery and anesthesia. It commonly impairs memory, attention, consciousness, and information-processing ability, yet its pathogenesis remains elusive. Studies suggest that anesthesia may be a risk factor for PND, and glucocorticoids are known to influence cognitive functions. Both abnormal and appropriate glucocorticoid levels can affect cognitive functions differently. This study explores the potential mechanism of dexamethasone preconditioning on postoperative cognitive function in a PND model involving long-term isoflurane anesthesia. Male C57BL/6 mice received a single dose of either dexamethasone or saline on the day of long-term isoflurane anesthesia. Spatial memory, contextual fear memory, permeability of the blood-brain barrier (BBB), and the expression of tight junction proteins were measured on the corresponding days following anesthesia. Results show that long-term isoflurane anesthesia causes spatial and episodic memory impairments in mice, while 5 mg/kg dexamethasone preconditioning ameliorated these impairments. Additionally, long-term isoflurane anesthesia increases BBB permeability and decreases the expression of tight junction proteins. In contrast, 5 mg/kg dexamethasone preconditioning mitigates these effects. Thus, dexamethasone preconditioning has a protective effect on memory function in mice subjected to long-term isoflurane anesthesia. |
