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Efficacy and safety of dexmedetomidine combined with sufentanil in ureteroscopic holmium laser lithotripsy |
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| รหัสดีโอไอ | |
| Creator | Tingting Zhao |
| Title | Efficacy and safety of dexmedetomidine combined with sufentanil in ureteroscopic holmium laser lithotripsy |
| Contributor | Danyang Wang |
| Publisher | Maejo University |
| Publication Year | 2567 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 18 |
| Journal No. | 2 |
| Page no. | 123 |
| Keyword | ureteroscopic holmium laser lithotripsy, dexmedetomidine, sufentanil |
| Website title | Maejo International Journal of Science and Technology |
| ISSN | 1905-7873 |
| Abstract | The efficacy and safety of combining dexmedetomidine with sufentanil for patients undergoing ureteroscopic holmium laser lithotripsy was investigated. A total of 90 consecutive patients who underwent this procedure were retrospectively selected. These patients were categorised into two groups based on their chosen anesthesia method: dexmedetomidine combined with sufentanil under non-intubated anesthesia group (DEX+SUF group) and the conventional intubated general anesthesia group (control group). Several parameters including efficacy, adverse effects, hemodynamics, inflammatory factors and variations in T lymphocytes were compared between the two groups. Patients in the DEX+SUF group exhibited notable advantages over those in the control group. They experienced significantly reduced operation time, awakening time, hospital stay, time to first feeding, time to ambulation, catheter-related bladder discomfort score, as well as lower incidences of hypotension, arrhythmia, gastrointestinal symptoms, impaired consciousness, and chills. The DEX+SUF group displayed greater stability in heart rate, mean arterial pressure and oxygen saturation at the mentioned time points compared to the control group. Regarding inflammatory factors, post-treatment levels of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-a), interferon-gamma (IFN-), cluster of differentiation 3 (CD3+), cluster of differentiation 4 (CD4+) and cluster of differentiation 8 (CD8+) in the DEX+SUF group were elevated compared to their pre-treatment levels. Furthermore, post-treatment IL-6, TNF-a and IFN- levels in the DEX+SUF group were significantly lower than those in the control group, while CD3+, CD4+ and CD8+ levels were significantly higher in the DEX+SUF group than in the control group. The combination of dexmedetomidine and sufentanil in ureteroscopic holmium laser lithotripsy significantly enhanced the hemodynamic stability of patients and reduced complications associated with anesthesia. This approach offers notable efficacy and safety while having a minimal impact on body inflammation and immune function. |
