|
An efficient Hantzsch synthesis of 1,4-dihydropyridines using p-toluenesulfonic acid under solvent-free condition |
|---|---|
| รหัสดีโอไอ | |
| Creator | 1. Masoud Nasr-Esfahani 2. Morteza Montazerozohori 3. Razieh Raeatikia |
| Title | An efficient Hantzsch synthesis of 1,4-dihydropyridines using p-toluenesulfonic acid under solvent-free condition |
| Publisher | Maejo University |
| Publication Year | 2557 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 8 |
| Journal No. | 1 |
| Page no. | 32 |
| Keyword | Hantzsch synthesis,1,4-dihydropyridines,p-toluenesulfonic acid,solvent-free synthesis |
| ISSN | 1905-7873 |
| Abstract | An efficient Hantzsch synthesis of various substituted 1,4-dihydropyridines from an aldehyde, a ?-dicarbonyl compound and ammonium acetate using p-toluenesulfonic acid in a solvent-free condition in the absence of any other co-catalyst is described. The process is simple and environmentally benign and the catalyst is commercially available and inexpensive. This method has the advantages of excellent yield (8096%) and short reaction time (5-20 min.). Irradiation of a typical 1,4-dihydropyridine leads to the corresponding pyridine. |
