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An alternative synthesis of (_+)-propranolol and (_+)-atenolol |
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| รหัสดีโอไอ | |
| Creator | 1. Aphiwat Teerawutgulrag 2. Rachaneebhorn Inkum 3. Pakawan Puangsombat 4. Nuansri Rakariyatham |
| Title | An alternative synthesis of (_+)-propranolol and (_+)-atenolol |
| Publisher | Maejo University |
| Publication Year | 2555 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 6 |
| Journal No. | 3 |
| Page no. | 372 |
| Keyword | beta-blockers,propranolol,atenolol |
| ISSN | 1905-7873 |
| Abstract | Herein, a simple synthesis pathway of beta-blockers starting from allyl amine is presented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol. |
