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Lipase-catalysed sequential kinetic resolution of alpha-lipoic acid |
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| รหัสดีโอไอ | |
| Creator | 1. Zhao Wang 2. Hong De Yan 3. Yin Jun Zhang 4. Li Jing Shen |
| Title | Lipase-catalysed sequential kinetic resolution of alpha-lipoic acid |
| Publisher | Maejo University |
| Publication Year | 2555 |
| Journal Title | Maejo International Journal of Science and Technology |
| Journal Vol. | 6 |
| Journal No. | 1 |
| Page no. | 152 |
| Keyword | Esterification,lipase-catalysed reactions,alpha-lipoic acid,sequential kinetic resolution |
| ISSN | 1905-7873 |
| Abstract | Lipase from Aspergillus sp. WZ002 was employed to kinetically resolve racemic alpha-lipoic acid by a sequential esterification process. Though the remoteness of this substrate's stereocentre from the reaction centre provided a significant challenge, the introduction of sequential kinetic resolution dramatically enhanced the lipase's enantioselectivity for esterification at the terminal carbonyl group, producing the desired (R)-enantiomer virtually enantiomerically pure. The enantiomeric excess of the (R)-enantiomer increased from 52% in the first step to 92% for in second step. |
