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ANTIHYPERTENSIVE AGENT AT BEDTIME IN PATIENTS WITH RESISTANT HYPERTENSION |
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| รหัสดีโอไอ | |
| Creator | Wannakon Chuemongkon, Thuraksorn Thura |
| Title | ANTIHYPERTENSIVE AGENT AT BEDTIME IN PATIENTS WITH RESISTANT HYPERTENSION |
| Publisher | Faculty of Medicine,Srinakharinwirot University |
| Publication Year | 2559 |
| Journal Title | Journal of Medicine and Health Sciences |
| Journal Vol. | 23 |
| Journal No. | 1 |
| Page no. | 36-44 |
| Keyword | resistant hypertension, antihypertensive agent at bedtime, non-dipper |
| ISSN | 0859-3299 |
| Abstract | Resistant hypertensions has a high prevalence in hypertensive patients who remain blood pressure above goal in spite of the concurrent use of 3 antihypertensive agents of different classes. Patients with resistant hypertension are at the greater risk of cardiovascular events, especially, non-dipper pattern. Concordantly, accumulating evidences showed that taking at least one antihypertensive agent at bedtime in patients with resistant hypertension diminished bedtime blood pressure; The prevalence of non-dipper and risk of cardiovascular events are better than taking all medications on awakening. However, clinical application of chronotherapy should be carefully considered for various factors including types of antihypertensive drugs, patients with comorbidities, adherence and individual variation. Further investigation, especially large randomized controlled trials, is needed to evaluate the definitive impact of dosing antihypertensives at bedtime in resistant hypertension. |
