Tramadol-induced Stevens-Johnson syndrome
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Creator Piyakan Limtanyakul, Piyakorn Poonyam, Rithee Smithrithee, Mana Taweevisit
Title Tramadol-induced Stevens-Johnson syndrome
Publisher Faculty of Medicine,Srinakharinwirot University
Publication Year 2556
Journal Title Journal of Medicine and Health Sciences
Journal Vol. 20
Journal No. 2
Page no. 4-8
Keyword Stevens-Johnson syndrome, Toxic epidermal necrolysis, Tramadol
ISSN 0859-3299
Abstract Stevens-Johnson syndrome and toxic epidermal necrolysis are acute and severe life-threatening allergic reactions. Their incidences in Thailand may be underestimated due to a lacking of reports. The etiologies of Stevens-Johnson syndrome/toxic epidermal necrolysis are numerous; drugs are the?most important causes. Not only well-known drugs, e.g. antibiotics, antiepileptics and NSAIDs, but also any drugs can be the cause of Stevens-Johnson syndrome/toxic epidermal necrolysis. Hereby we report a 20 years old Thai male presenting with high-grade fever with extensive detachment of epidermis?and erosion of mucocutaneous membrane for 3 days. The patient had taken tramadol. The dermatopathology was compatible with Stevens-Johnson syndrome. The serology revealed positive dengue Immunoglobulin G. The final diagnosis was dengue fever with Stevens-Johnson syndrome.?We report a case of Stevens-Johnson syndrome from tramadol.

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