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N-Aroylbenzimidazoles as efficient new reagents for a greener esterification reaction under solvent-free conditions |
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| รหัสดีโอไอ | |
| Creator | Baramee Phungpis |
| Title | N-Aroylbenzimidazoles as efficient new reagents for a greener esterification reaction under solvent-free conditions |
| Contributor | Kanokkan Worawut |
| Publisher | Rangsit University |
| Publication Year | 2565 |
| Journal Title | Journal of Current Science and Technology |
| Journal Vol. | 12 |
| Journal No. | 2 |
| Page no. | 211-223 |
| Keyword | N-aroylbenzimidazoles, aroylation reagent, esterification, grinding |
| URL Website | https://jcst.rsu.ac.th/ |
| ISSN | 2630-0656 |
| Abstract | Due to the increasing demand for green technology and its numerous advantages over conventional methodologies, this work has received interest for the development of a facile and efficient method for the synthesis of esters using benzimidazole chemistry. N-aroylbenzimidazole derivatives 2a-d synthesized herein were found to be highly active acylation reagents, readily leading to high-yielding syntheses of ester products under solvent-free conditions without the need for a catalyst. A wide variety of esterification reactions between alcohols 1a-e and N-aroylbenzimidazoles 2a-d were carried out by grinding the mixtures, which were converted to their ester products 3a-t in a simple synthetic procedure with yields in the range of 84% to 96% and recovery of the by-product benzimidazole (4) (80-93%). Compound 4 can be reused for the preparation of N-aroylbenzimidazoles 2a-d without significant loss of efficiency. The advantages of this current methodology are the simple procedure; the absence of hazardous organic solvents; catalyst- and solvent-free conditions with high yields, low reaction temperatures, and short reaction times; and eco-friendly reactions generating no waste and allowing reagents to be recovered and reused. |
