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Effects of carotenoid-rich jelly consumption on changes in blood concentrations of carotenoids and lipid profiles among obese men |
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| รหัสดีโอไอ | |
| Creator | Jintana Sirivarasai |
| Title | Effects of carotenoid-rich jelly consumption on changes in blood concentrations of carotenoids and lipid profiles among obese men |
| Contributor | Onanong Promwong, Pornrat Sinchaipanit, Wutarak Puengputtho |
| Publisher | The Pharmacological and Therapeutic Society of Thailand |
| Publication Year | 2566 |
| Journal Title | Journal of Basic and Applied Pharmacology |
| Journal Vol. | 3 |
| Journal No. | 1 |
| Page no. | O1-17 |
| Keyword | obesity, carotenoid, plasma beta carotene, oxidative stress, high-sensitivity C reactive protein |
| URL Website | https://li01.tci-thaijo.org/index.php/JBAP |
| Website title | เว็บไซต์คลังข้อมูล |
| ISSN | 2774-0854 (Online) |
| Abstract | Excessive fat accumulation leads to the generation of reactive oxygen species, oxidative stress, chronic inflammation, and abnormal lipid signaling pathways that potentially result in metabolic dysregulation. Beta carotene is one of the main provitamin A carotenoids in the diet which has potentially beneficial effects on health. Epidemiological studies have linked high circulating concentrations of beta carotene and metabolic diseases such as obesity, diabetes and cancer. In this pilot randomized controlled trial study, we aimed to determine the effect of carrot jelly consumption on clinical and biochemical parameters related to metabolic syndrome in men with obesity. A group of men with obesity underwent dietary supplementation with carrot jelly rich in beta carotene (N=10) or placebo (N=10) daily for 3 months. The treatment group showed significantly high levels of plasma beta-carotene at 1 month (263.6 ±1.90 ng/mL) and 3 month (284.6 ±1.65 ng/mL) after supplementation compared to the baseline (72.4 ±2.34 ng/mL, with p<0.05). After 3 months, the treatment group also showed lower blood pressure; lower plasma low-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, and malondialdehyde concentrations; and higher plasma oxygen radical absorbance capacity (all p<0.05) compared to baseline. In the follow-up periods, these biochemical markers among the placebo group remained unchanged. Dietary carotenoid supplementation may have beneficial effects in men with obesity and other related metabolic diseases such as dyslipidemia and hypertension. |
