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Inhibitory activities of vegetable juices on digestive enzymes for starch and sugar digestions |
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| รหัสดีโอไอ | |
| Creator | Nanteetip Limpeanchob |
| Title | Inhibitory activities of vegetable juices on digestive enzymes for starch and sugar digestions |
| Contributor | Matusorn Wongon, Kanchana Muengfa, Kanittaporn Trisat |
| Publisher | The Pharmacological and Therapeutic Society of Thailand |
| Publication Year | 2565 |
| Journal Title | Journal of Basic and Applied Pharmacology |
| Journal Vol. | 2 |
| Journal No. | 2 |
| Page no. | O62-73 |
| Keyword | diabetes, α-glucosidase, sugar digestion, digestive enzyme, vegetables |
| URL Website | https://li01.tci-thaijo.org/index.php/JBAP |
| Website title | เว็บไซต์คลังข้อมูล |
| ISSN | 2774-0854 (Online) |
| Abstract | Hyperglycemia, or raised blood sugar, is a common effect of uncontrolled diabetes. Besides drug therapy, lifestyle modification, particularly a healthy diet, is important. Vegetable-based diet consumption is highly recommended; thus, the present study aimed to investigate and identify types of vegetables possessing potential for management of blood glucose levels. Nineteen vegetables were selected to prepare freeze-dried vegetable juices. a-Glucosidase inhibitory activity was tested using natural substrates (maltose and sucrose) in comparison with a synthetic glucose derivative (pNPG). a-Amylase was also tested. The enzyme inhibitory activities of heated vegetable samples were also monitored to investigate the influence of cooking conditions. The results indicated that among all tested samples holy basil, sweet basil, and okra possessed high potential as a-glucosidase inhibitors in which 50% inhibitory concentration (IC50) of all three samples were lower than that of acarbose regardless of type of substrates. Juices from holy basil, sweet basil, and okra exhibited non-competitive a-glucosidase inhibition whereas acarbose showed competitive inhibition. Boiling differently affected a-glucosidase inhibitory activities of each vegetable but it seems not to have much effect on holy basil, sweet basil, and okra activity. In conclusion, consumption of these vegetables may reduce carbohydrate digestion, delay glucose absorption, and reduce postprandial blood glucose, thus being of benefit not only for diabetic patients but also for people with a high risk for developing diabetes, as well as generally healthy people. |
