|
Comparison of dynamics of HIV-1 coreceptor usage in a long-term antiretroviral treatment adolescent by genotypic and phenotypic assays |
|---|---|
| รหัสดีโอไอ | |
| Creator | 1. Sayamon Hongjaisee 2. Sartsin Chaipong 3. Tanawan Samleerat |
| Title | Comparison of dynamics of HIV-1 coreceptor usage in a long-term antiretroviral treatment adolescent by genotypic and phenotypic assays |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2562 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 52 |
| Journal No. | 1 |
| Page no. | 14-17 |
| Keyword | HIV, coreceptor usage, tropism, CCR5, genotypic predictors |
| URL Website | https://www.tci-thaijo.org/index.php/bulletinAMS/index |
| Website title | Journal of Associated Medical Sciences |
| ISSN | 25396056 |
| Abstract | The HIV-1 coreceptor usage can be determined by both phenotypic and genotypic assays. However, the phenotypic assays are expensive, time consuming, and require specialized laboratories, more interest has been driven toward genotypic assays, which are based on the prediction of coreceptor usage from V3 amino acid sequences using genotypic tools. Currently, they are preferred because of their accessibility, rapid results, and the low cost of these techniques. Nevertheless, the predictions are not always accurate; a false prediction of X4 variants may lead to unnecessarily precluding patients who could have benefited from receiving CCR5 inhibitors whereas a false prediction of R5 variants may lead to the reemergence of X4-strains under CCR5 inhibitors pressure. Herein, we discussed a case that had evidence of a coreceptor usage trend to be more of an X4 phenotype based on genotypic predictors, but it contrasted with phenotypic assay, which only voted to R5. |
