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Assessment of CareStartTM G6PD RDT for G6PD deficiency screening in newborns and malaria diagnosed subjects in the Northern Thailand |
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| รหัสดีโอไอ | |
| Creator | 1. Nattasit Pienthai 2. Chedtapak Ruengdit 3. Suphara Manowong 4. Kanyakan Kongthai 5. Kritsanee Maneewong 6. Kankanitta Pongmorn 7. Maneewan Inta 8. Nardlada Hhantikul 9. Aungkana Saejeng 10. Sakorn PornprasertNattasit Pienthai 11. Chedtapak Ruengdit 12. Suphara Manowong 13. Kanyakan Kongthai 14. Kritsanee Maneewong 15. Kankanitta Pongmorn 16. Maneewan Inta 17. Nardlada Hhantikul 18. Aungkana Saejeng 19. Sakorn Pornprasert |
| Title | Assessment of CareStartTM G6PD RDT for G6PD deficiency screening in newborns and malaria diagnosed subjects in the Northern Thailand |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2562 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 52 |
| Journal No. | 1 |
| Page no. | 78-82 |
| Keyword | Accuracy, CareStartTM G6PD RDT, Fluorescent spot test, G6PD deficiency, ScreeningAccuracy, CareStartTM G6PD RDT, Fluorescent spot test, G6PD deficiency, Screening |
| URL Website | https://www.tci-thaijo.org/index.php/bulletinAMS/index |
| Website title | Journal of Associated Medical Sciences |
| ISSN | 25396056 |
| Abstract | Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited enzymatic disorder associated with severe neonatal hyperbilirubinemia and acute hemolysis after exposure to certain drugs or infections. The most common test for screening G6PD deficiency is fluorescent spot test which is rapid and convenient. However, fluorescent spot test needs tools and skills in diagnosis and interpretation of the results. CareStartTM G6PD Rapid Diagnosis Test (RDT) is an enzyme chromatographic strip test based on reduction of colorless nitro blue tetrazolium into formazan which gives purple color and the results could be read within 10 minutes. Objective: This study aimed to analyze the sensitivity, specificity and accuracy of CareStartTM G6PD RDT for screening of G6PD deficiency in newborn and subjects with malaria diagnosis. Materials and methods: This study was conducted from December 2017 to February 2018. G6PD diagnostic tests including fluorescent spot test and CarestartTM G6PD RDT were performed in 196 newborns aged varied from 1 day to 12 years and 48 subjects with malaria diagnosis. The efficiency of CareStartTM G6PD RDT was analyzed by comparing with the reference method, fluorescent spot test. Results: CareStartTM G6PD RDT demonstrated 100% sensitivity, 100% specificity and 100% accuracy for screening of G6PD deficiency in malarial diagnosed samples. However, it presented invalid results up to 27.04% in newborns. Therefore, sensitivity, specificity and accuracy were not applicable in this group. Conclusion: CareStartTM G6PD RDT could be used for preliminary screening of G6PD deficiency in malarial diagnosed samples. However, it should be improved to reduce the invalid results in newborns. |
