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Anti-proliferative activity on drug-sensitive and drug-resistant erythroleukemic cells of Samor Pipek (Terminalia bellirica (Gaertn.) Roxb.) fruit extracts |
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| รหัสดีโอไอ | |
| Creator | 1. Winit Choiprasert 2. Watcharaporn Khumsan 3. Pimchanok Malasaem 4. Bajaree Phithakham |
| Title | Anti-proliferative activity on drug-sensitive and drug-resistant erythroleukemic cells of Samor Pipek (Terminalia bellirica (Gaertn.) Roxb.) fruit extracts |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2560 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 50 |
| Journal No. | 1 |
| Page no. | 64-70 |
| Keyword | Samor Pipek, erythroleukimic cell, K562, drug resistance. |
| ISSN | 25396056 |
| Abstract | Introduction: Cancer is a major cause of death in Thailand. Drug resistance in cancer is a significant obstacle to the success of chemotherapy in cancer. There are several researches indicate the potential of herb in the inhibition of cancer cell proliferation for applying in cancer treatment.Objectives: To study anti-proliferative activity of Samor Pipek (Terminalia bellirica (Gaertn.) Roxb.) fruit extracts against drug-sensitive and drug-resistant erythroleukemic cells.Materials and methods: Samor Pipek fruits were extracted with acetonitrile, ethanol, and water. Anti-proliferative activity on drug-sensitive and drug-resistant erythroleukemic cells were determined by flow cytometer.Results: Concentration of acetonitrile, ethanol and water extracts for inhibiting drug-sensitive erythroleukemic cell proliferation by 50% (IC50) were 24.70?8.05 ug/mL, 24.02?2.51 ug/mL and 13.09?3.40 ug/mL, respectively. IC50 of acetonitrile, ethanol and water extracts to inhibit drug- resistant erythroleukemic cell proliferation were 13.95?2.50 ug/mL, 20.45?10.10 ug/mL and 27.39?7.16 ug/mL, respectively. The resistance values of acetonitrile, ethanol and water extracts were 0.56, 0.85 and 2.09, respectively.Conclusion: Acetonitrile, ethanol and water extracts could inhibit drug-sensitive and drug-resistant erythroleukemic cell proliferation in ug/mL range. |
