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Effectiveness of double dose in single donor platelet preparation by the automated blood cell separators in continuous and intermittent flow system |
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| รหัสดีโอไอ | |
| Creator | 1. Warangkana Soloslikit 2. Pichet Vienghok |
| Title | Effectiveness of double dose in single donor platelet preparation by the automated blood cell separators in continuous and intermittent flow system |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2559 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 49 |
| Journal No. | 3 |
| Page no. | 400-411 |
| Keyword | Single donor platelet, double dose, pre-count platelets, post-count platelets, platelet yield |
| ISSN | 25396056 |
| Abstract | Background: To prepare single donor platelet (SDP) with good quality and sufficient quantity, beside safety to donors and patients, efficient and less costly automate blood cell separators also be considered.Objectives: To study the double-dose SDP products prepared from two automated blood cell separators having different principles. To compare platelet products in donors before, immediately after donation, and two weeks after donation. To evaluate change of average cost after double dose SDP preparation was implemented.Materials and methods: Semi-randomized study was performed in double-dose platelet donor (2 groups of 45 donors) in Blood Bank Unit, Phare Hospital during March to September 2015. Two automated blood cell separators, continuous flow: Trima Accelฎ and intermittent flow: Haemonetics MCS plus /UPPฎ systems were compared in terms of platelet products, pre/post-count platelets and hematologic values before, immediately, and two weeks after donation. Operation and efficiency of machine as well as average cost per dose of SDP preparation in 20132015 were also studied. Result: Quality and yield of platelet products obtained from Trima Accelฎ were significantly greater than those from Haemonetics MCS plus/UPPฎ; volume 444.0ฑ41.5 mL, platelet yield 6.2ฑ0.6x1011 cells, platelet 11.4ฑ1.2 units for Trima Accelฎ and volume 385.1ฑ87.1 mL, platelet yield 5.5ฑ0.7x1011 cells, platelet 9.6ฑ2.2 units for Haemonetics MCS plus/UPPฎ (p<0.001). After two weeks of donation, donors using Trima Accelฎ had significantly higher post-count platelet than those of Haemonetics MCS plus/UPPฎ. Collection efficiency of Trima Accelฎ was significantly higher than Haemonetics MCS plus/UPPฎ (p=0.042). Processing time per procedure of Trima Accelฎ and Haemonetics MCS plus/UPPฎ was averagely 82.3ฑ13.7 minutes and 85.6ฑ21.6 minutes, respectively, with no statistical significance. In 2015, cost per dose of SDP preparation for patients in Phrae Hospital decreased to 24.7% after increasing double dose SDP products to 34.8%. Conclusion: Platelet yield products from Trima Accelฎ was superior to those from Haemonetics MCS plus/UPPฎ. After two weeks, double dose SDP donors donated by Trima Accelฎ had increased post-count platelets, suggesting that repeat donation can be done before four weeks. Both blood cell separators has no difference in processing time per procedure and double dose SDP preparation decreased cost of management. |
