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Human leukocyte antigen-associated uveitis in Thai population: Brief review |
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| รหัสดีโอไอ | |
| Creator | 1. Nampeung Anukul 2. Nipapan Leetrakool 3. Kessara Pathanapitoon |
| Title | Human leukocyte antigen-associated uveitis in Thai population: Brief review |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2558 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 48 |
| Journal No. | 1 |
| Page no. | 10-17 |
| Keyword | Human leukocyte antigen, HLA, uveitis, disease association |
| ISSN | 1255347 |
| Abstract | Human Leukocyte Antigen (HLA) has been associated with several immune-mediated diseases,malignancies and infectious diseases. Due to the HLA complexity and polymorphisms, several typesof HLA have been used as the molecular markers in diagnosis. Among different ethnic groups, HLA isgenetically diverse resulting in the differences of disease susceptibility. The study of HLA in Thai populationwill help an understanding of diseases pathogenesis and the genetic linkage leading to the developmentof genetic markers that are specific to Thai population. Vogt-Koyanagi-Harada (VKH) syndrome,HLA-B27-associated acute anterior uveitis (AAU) and Beh?et's disease (BD) were found to be the majorcauses of non-infectious and autoimmune-related uveitis in Thai patients. Several etiologic studies inWestern, European and other Asian populations reported the strong association between HLA-DR4 andVKH, HLA-B27 and AAU as well as HLA-B51 and BD. However, few in HLA-B27 and none in HLA-B51 andHLA-DR4 related uveitis study have been reported in Thailand. This briefly review discusses the associationof HLA and non-infectious uveitis among populations and future research aspects for Thai populations. |
