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Prevalence of glucose-6-phosphate dehydrogenase deficiency (G-6-PD) using methemoglobin reduction test in blood donors of Chiang Mai Province |
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| รหัสดีโอไอ | |
| Creator | 1. Poonsub Palacajornsuk 2. Phaophan Sriwangpon |
| Title | Prevalence of glucose-6-phosphate dehydrogenase deficiency (G-6-PD) using methemoglobin reduction test in blood donors of Chiang Mai Province |
| Publisher | Faculty of Associated Medical Sciences, Chiang Mai University |
| Publication Year | 2558 |
| Journal Title | Journal of Associated Medical Sciences |
| Journal Vol. | 48 |
| Journal No. | 1 |
| Page no. | 29-33 |
| Keyword | G-6-PD deficiency, methemoglobin reduction test, blood donors |
| ISSN | 1255347 |
| Abstract | Introduction: Glucose-6-phosphate dehydrogenase is an enzyme that protects RBCs from oxidative damageby free radicals in food, drug, chemical or infectious conditions. If blood from donors with G-6-PD deficiencyis transfused to patients, it can cause hemolysis, especially in exchange transfusion for neonate.Objective: To study the prevalence of G-6-PD deficiency in blood donors of Chiang Mai Province usingmethemoglobin reduction test.Materials and methods: One thousand and seventeen EDTA blood samples obtained from blood donors atRegional Blood Center X Chiang Mai, Thai Red Cross Society were subjected to screen of G-6-PD deficiency usingmethemoglobin reduction test.Results: Nine hundred and ten samples (89.5%) were found to have normal G-6-PD activity. Thirty threesamples (3.2%) were partially deficient and 74 samples (7.3%) were completely deficient for G-6-PD enzyme.The prevalence of G-6-PD deficiency in blood donors was estimated to be 10.5%, with males being 6.4% andfemales being 4.1%.Conclusions: Prevalence of G-6-PD deficiency in blood donors of Chiang Mai Province is considerably high.Thus, screening for G-6-PD deficiency among blood donors in this area and other areas with high prevalence isrecommended in order to suggest the donation of blood components instead of red blood cells. |
