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Preclinical Studies of Microbial Feed Additives on Laboratory Animals |
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| รหัสดีโอไอ | |
| Creator | Alexey Andreevich Boyko, Andrey Georgievich Koshchaev, Yury Andreevich Lysenko, Azamat Khazretovich Shantyz, Albina Vladimirovna Luneva, Anna Alexandrovna Shirina |
| Title | Preclinical Studies of Microbial Feed Additives on Laboratory Animals |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2564 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 12 |
| Journal No. | 11 |
| Page no. | 12A11H: 1-13 |
| Keyword | Preclinical experiment, SBT-Lacto feed additive, Acute toxicity, Chronic toxicity, Irritant effect, Harmlessness, Rats, Pathological effect, Mice, Rabbits. |
| URL Website | http://TuEngr.com/Vol12-11.html |
| Website title | ITJEMAST V12(11) 2021 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | The object of research was a microbial feed additive SBT-Lacto, containing a dry culture of lactic acid bacteria: Bifidobacterium lactis (2.5-3.0 %), Lactobacillus acidophilus (2.53.0%), Streptococcus thermophilus (2.53.0%), Lactobacillus delbrueckii ssp. Bulgaricus (2.53.0 %), and fillers: edible citrus fiber (14.0-15.0 %), maltodextrin (76.084.0%), to improve the digestibility of mixed feed, increase the safety, growth, and productivity of farm animals, including poultry. The work aimed to determine the acute and chronic toxicity, as well as the irritating effect of the SBT-Lacto feed additive on laboratory animals (mice, rats, rabbits). In the course of research work, clinical, pathoanatomic, biochemical, and morphological studies of the blood of experimental animals were carried out. As a result of the research, it was found that the feed additive SBT-Lacto at a dose of 7500 mg/kg of body weight does not have a toxic effect on the body of laboratory animals. According to the degree of exposure to the body of warm-blooded animals, the feed additive refers to substances that are not very dangerous. The microbial feed additive SBT-Lacto can be recommended for use in practical animal husbandry, including poultry farming. |
