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Efficient and Low-cost Extraction Methods for Pharmaceutical Compounds of Carbamazepine and Caffeine |
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| รหัสดีโอไอ | |
| Creator | N. Mohamad-Nasir, S. Abdul-Talib, N. F. Lokman, S. N. Hashim, C. C. Tay |
| Title | Efficient and Low-cost Extraction Methods for Pharmaceutical Compounds of Carbamazepine and Caffeine |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2564 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 12 |
| Journal No. | 9 |
| Page no. | 12A9J: 1-9 |
| Keyword | Caffeine extraction, Solid Phase Extraction (SPE), Carbamazepine extraction, Liquid-liquid Extraction (LLE), Caffeine Calibration Curve, Pharmaceutical compounds, HPLC, Carbamazepine retention time. |
| URL Website | http://TuEngr.com/Vol12_9.html |
| Website title | ITJEMAST V12(9) 2021 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | This study focuses on determining the efficient extraction methods between Liquid-liquid Extraction (LLE) and Solid Phase Extraction (SPE) for carbamazepine and caffeine. Optimization on methanol volume was investigated and evaluated through average recovery percentage. Overall, the analytical average recovery percentage of carbamazepine and caffeine was greater than 80% for LLE, while the average recovery percentage for the SPE method was very low (5% to 35%). Optimum methanol volume for carbamazepine and caffeine extraction was determined at 11 mL. In conclusion, the low-cost LLE method using 11 mL methanol was selected as the efficient method and optimum methanol volume for carbamazepine and caffeine extraction. Statistical analysis showed a significant difference between the methods. The finding sheds light on the reliable and consistent result in further instrumental analysis. |
