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Effects of Hydroxyurea on Some Adhesion Molecules in Sickle Cell Anemia Patients |
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| รหัสดีโอไอ | |
| Creator | Nesrin Tarbiah, Maryam M. Alhemadi, Huda S. Almutairi, Reema S. Alamri, Galila F. Zaher, Alia M. Sabban, Nuha A. Alkhattabi |
| Title | Effects of Hydroxyurea on Some Adhesion Molecules in Sickle Cell Anemia Patients |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2564 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 12 |
| Journal No. | 8 |
| Page no. | 12A8S: 1-11 |
| Keyword | Endothelium selectin (E-selectin), Platelet selectin (P-selectin), Lymphocytes (L-selectin), Sickle cell anemia (SCA), Cell adhesion molecules, Vaso-occlusive crises, Intracellular adhesion molecule-1, Vascular cellular adhesion molecule-1 (VCAM-1), Hydroxyurea (HU), ELISA. |
| URL Website | http://TuEngr.com/Vol12_8.html |
| Website title | ITJEMAST V12(8) 2021 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | Sickle cell anemia (SCA) is a genetic disorder in the blood that is characterized by progressive organ malfunction, painful vaso-occlusive crises, and severe hemolytic anemia. This case-control aimed to compare study of this study is to determine the expression level of adhesion molecules: Vascular Cellular Adhesion Molecule-1 (VCAM-1), Intracellular Adhesion Molecule-1 (ICAM-1), Platelet selectin (P-selectin), and Endothelium selectin (E-selectin) in plasma samples using ELISA technique. This research included 78 males and females, 22 of whom were control individuals, and the rest were divided into 2 groups: steady-state sickle cell patients (SCA), and patients under hydroxyl-urea treatment (SCAHU). The study results indicated that plasma E- and P-selectin expression levels were significantly higher in the SCA group when compared to control groups, but there were no significant differences between the SCAHU and SCA groups for both E and P selectins. There was an increase in the ICAM-1 and VCAM-1 levels in the patient groups when compared to the control group, but they were not statistically significant. Our findings suggest that high expression of P-selectin, E-selectin, VCAM-1, and ICAM-1 predisposes patients to severe manifestations of SCA. |
