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Biosafety of Autochton Strains of Microorganisms-Probion and Their Joint Composition |
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| รหัสดีโอไอ | |
| Creator | Andrei Koshchayev, Albina Luneva, Yury Lysenko, Alexander Lysenko, Azamat Shantyz |
| Title | Biosafety of Autochton Strains of Microorganisms-Probion and Their Joint Composition |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2564 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 12 |
| Journal No. | 1 |
| Page no. | 12A1L: 1-11 |
| Keyword | Acute toxicity, Chronic toxicity, Lactobacillus, Harmlessness, Toxigenicity, Probiotic, Virulence, Probiont strains, Mice, Rats. |
| URL Website | http://TuEngr.com/Vol12_1.html |
| Website title | ITJEMAST V12(1) 2021 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | The research work presents the results of studying the virulence, toxigenicity, and various types of toxicity of probiont strains isolated and identified by modern molecular genetic and microbiological methods from wild birds' gastrointestinal tract. In this work, laboratory animals were used for research, particularly nonlinear mice, rats, and albino rabbits. As a result of a complex of preclinical studies, it was revealed that experimental autochthonous strains of lactobacilli do not show signs of virulence, toxicity, toxicity, and a positive reaction to the production of hemolysin. In experiments on acute and chronic toxicity, regardless of the concentration of the studied strains introduced into the organism of laboratory animals, as well as their joint consortium in the composition of the probiotic, no death of the experimental animals was revealed, there were no signs of health disorders and body weight loss during the experiment. In general, the study results showed that the studied cultures of microorganisms and their consortium do not have a toxic effect on the organism of laboratory animals, both with a single and long-term use in the diet, which confirms their safety. |
