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EVALUATION OF TOXICOLOGICAL PARAMETERS OF DAPS-25K AFTER A SINGLE INTRAGASTIRIC ADMINISTRATION TO MICE AND GUINEA PIGS |
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| รหัสดีโอไอ | |
| Creator | R.O. Vasiliev, E.I. Troshin, S.A. Brevnova, N. Yu. Yugatova, A.V. Shishkin, I.L. Vasilyeva, A. N. Kulikov |
| Title | EVALUATION OF TOXICOLOGICAL PARAMETERS OF DAPS-25K AFTER A SINGLE INTRAGASTIRIC ADMINISTRATION TO MICE AND GUINEA PIGS |
| Contributor | - |
| Publisher | TuEngr Group |
| Publication Year | 2563 |
| Journal Title | International Transaction Journal of Engineering, Management, & Applied Sciences & Technologies |
| Journal Vol. | 11 |
| Journal No. | 10 |
| Page no. | 11A10P: 1-13 |
| Keyword | Autopsy of dead animals, Diacetophenonyl selenide, DAPS-25k, Acute toxicity, Experiment mice, Experiment guinea pigs, Intragastric administration, Organic forms of selenium. |
| URL Website | http://TuEngr.com/Vol11_10.html |
| Website title | ITJEMAST V11(10) 2020 @ TuEngr.com |
| ISSN | 2228-9860 |
| Abstract | Lack of selenium in food chains contributes to the development of about 40 diseases in animals. In conditions of acute selenium deficiency in agroecosystems, enrichment of plant feed for animals with selenium with the help of food additives is becoming increasingly important. However, inorganic forms of selenium are highly toxic and their use requires strict veterinary control. Therefore, feed additives containing organoselenium compounds are of the greatest interest. One of these additives is DAPS-25k, a new generation organoselenium preparation synthesized by domestic scientists. Thus, this work aimed to determine the parameters of acute toxicity of DAPS-25k after a single intragastric administration to mice and guinea pigs. It was found that high doses (25-50 mg/kg) of DAPS-25k after a single intragastric administration cause a decrease in general body temperature and live weight accompanied with depression and pulmonary edema. Guinea pigs were more sensitive to DAPS-25k, and LD50 in them was 15.8 ? 3.45 mg/kg, and in mice 19.6 ? 4.452 mg/kg. |
