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Paper spray mass spectrometry: A new rapid confirmation method for methamphetamine |
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| รหัสดีโอไอ | |
| Creator | Wachirawit Tungtananuwat |
| Title | Paper spray mass spectrometry: A new rapid confirmation method for methamphetamine |
| Publisher | Phetchaburi Rajabhat University |
| Publication Year | 2564 |
| Journal Title | Interdisciplinary Research Review (IRR) |
| Journal Vol. | 16 |
| Journal No. | 1 |
| Page no. | 1-4 |
| Keyword | Methamphetamineวpaper spray mass spectrometryวOrbitrap |
| URL Website | https://ph02.tci-thaijo.org/index.php/jtir |
| Website title | Interdisciplinary Research Review (IRR) |
| ISSN | 2697-536X |
| Abstract | Paper spray mass spectrometry (PS-MS) is amenable for analyzing drugs and other compounds in biological samples. It has provided a rapid, qualitative, and quantitative ambient ionization method for biomolecules analysis to an alternative to traditional sample preparation and chromatography. This research aimed to study the efficiency of postmortem urine metham-phetamine (METH) identification using PS-MS (orbitrap) compared with the Online-SPE-LC-MS/MS method. Twenty-one of METH positive urine and four METH negative urine from May 2017-Dec 2019 were randomly sampled and analyzed for METH concentration using both methods. The qualitative results obtained by the PS-MS method founding that twenty-one of METH positive urine cases were passing of three criteria parameters of PS-MS method with the true positive rate equal to 100% and the quantitative results founding that METH concentrations determined by PS-MS method were significantly higher than the results from Online-SPE-LC-MS/MS method (Paired t-Test, P-value<0.05). PS-MS method can save time 7.5 fold as compared to the Online-SPE-LC-MS/MS method. In conclusion, PS-MS can be used for rapid screening and confirmation of urine METH. |
