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Taste-masking of pills by coating with a wax emulsion made from Calathea lutea |
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| รหัสดีโอไอ | |
| Creator | Shisanupong Anukanon |
| Title | Taste-masking of pills by coating with a wax emulsion made from Calathea lutea |
| Contributor | Chaiyong Rujjanawate |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2565 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 18 |
| Journal No. | 3 |
| Page no. | 67-76 |
| Keyword | Calathea lutea (Aubl.) E.Mey. ex Schult, Cauassรบ wax, Pill coating, Emulsion, Sensory evaluation |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal of Pharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | The wax covering the leaf of Calathea lutea is a promising naturally resourced material and the use of this natural wax, as a pill coating, requires investigation. This study determined the required hydrophilic-lipophilic balance (HLB) values of this wax, to formulate both the most stable emulsion and the most effective taste-masking preparation for human use. Materials and method: The wax from C. lutea was prepared in a series of six emulsion formulations, with HLB values ranging from 9 to 14, using the beaker method. The optimal required HLB value was determined by using microscopic droplet size analysis. Bitter traditional herbal pills (made from Andrographis paniculata) were then coated with the optimal emulsion formulation in order to evaluate the masking of the bitter taste in healthy volunteers. Results: The results revealed that an emulsion formulation, with the required hydrophilic-lipophilic balance (HLB) of 12, was the most stable and was suitable for coating the bitter herbal pills. In a sensory evaluation in healthy participants in term of onset time exposed bitter taste, the formulation effectively masked the taste of bitter traditional herbal pills when compared to the uncoated pills. The physical characteristics of its coating layer were acceptable. Conclusion: This study suggests that an emulsion made from the wax of C. lutea can effectively mask the bitterness of the andrographis pill. This natural wax material can therefore be used as an alternative pill coating in pharmaceutical preparations. |
