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A Meta-Analysis of Randomized Controlled Trial on Efficacy of Naltrexone/Bupropion for Anthropological Parameter, Lipid profile, Blood Glucose and Blood Pressure |
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| รหัสดีโอไอ | |
| Creator | Wiraphol Phimarn |
| Title | A Meta-Analysis of Randomized Controlled Trial on Efficacy of Naltrexone/Bupropion for Anthropological Parameter, Lipid profile, Blood Glucose and Blood Pressure |
| Contributor | Kittisak Wichaiyo, Kritsanee Saramunee, Bunleu Sungthong |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2561 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 14 |
| Journal No. | 3 |
| Page no. | 56-69 |
| Keyword | Naltrexone/Bupropion, anthropological parameters, lipid profile, blood glucose, blood pressure |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Previous studies reported that Naltrexone/Bupropion (NB) improved several metabolic parameters but there were no a meta-analysis in these outcomes. Objectives : This study aimed to assess NB efficacy for improving anthropological parameters, lipid profile, blood glucose and blood pressure. Material and methods : The databases included PubMed, Scopus, CINAHL from inception to August 2017. For this analysis, we selected randomized placebo versus NB intervention trials. We performed a quality assessment of the retrieved studied using Jadad's scoring and Cochrane's risk of bias assessment. Results : Six studies (11,733 participants) met inclusion criteria. Meta-analysis revealed a reduction in body weight (weight mean difference; WMD -5.02 kg; 95%CI : -6.49, -3.54), waist circumference (WMD -3.70 cm; 95% CI -4.60, -2.80). Similar results were observed for LDL-cholesterol (WMD -3.34 mg/dL; 95% CI -5.67, -1.02), TG (WMD -11.90 mg/dL; 95% CI -14.78, -9.02) and increased HDL significantly (WMD 3.82 mg/dL; 95% CI 2.88, 4.77). Moreover, participants administrated NB significant reduction in fasting insulin (WMD -0.91 mIU/mL; 95% CI -1.25, -0.57) and HOMA-IR (WMD -0.68; 95% CI -0.54, -0.21). No serious adverse effects were found in either the NB or comparator groups. Conclusion : NB improved anthropological parameters, lipid profile, fasting insulin and HOMA-IR. |
