|
Regulation of CYP2A expression and its role in metabolism |
|---|---|
| รหัสดีโอไอ | |
| Creator | Kanokwan Jarukamjorn |
| Title | Regulation of CYP2A expression and its role in metabolism |
| Contributor | Thanyalak Boonmaton |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2561 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 14 |
| Journal No. | 3 |
| Page no. | 1-15 |
| Keyword | cytochrome P450 2A, CYP2A6, CYP2A13, nuclear receptor |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Cytochrome P450 2A (CYP2A) plays a role in metabolism of exogenous substances including drugs and procarcinogens. This article aims to review regulatory expression of CYP2A gene and CYP2A isoforms found in human and animals, including roles of CYP2As in metabolism to obtain the overview information of CYP2A for clinical application. CYP2A6 and CYP2A13 are CYP2A expressed and showed enzyme activity in human. Both are the main enzymes in metabolism of interesting exogenous substances such as nicotine and nitrosamines procarcinogens in cigarette including high toxic and mutation induced substances. In addition, some roles of these human CYP2As are similar to mouse and rat CYP2As. Regulation of these human CYP2As involve several nuclear receptors depended on an inducer and an isoform responsible for metabolism. Moreover, roles of CYP2A depend on position and level of expression of the enzyme, by which the major responsible isoform for metabolism becomes inferior to the higher expressed isoform. Therefore, the review on regulation of CYP2A expression and its role in metabolism brings information on involvement of CYP2A and clinical significances. |
