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Effect of Laser Acupuncture on the Activity of Antioxidant Enzymes in Focal Cerebral Ischemic Rat |
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| รหัสดีโอไอ | |
| Creator | Jinatta Jittiwat |
| Title | Effect of Laser Acupuncture on the Activity of Antioxidant Enzymes in Focal Cerebral Ischemic Rat |
| Contributor | - |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2560 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 13 |
| Journal No. | 3 |
| Page no. | 68-78 |
| Keyword | stroke, laser acupuncture, Baihui (GV20) point, antioxidant enzymes |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Stroke has been regarded as a major cause of mortality, morbidity and prolonged neurological disability particularly in elderly. However, the effective protective and therapeutic strategies had not yet available. Therefore, the development of novel strategy for patients who have suffered from a stroke is urgently required. This study aimed to determine the effect of laser acupuncture on cerebral ischemic rat. Male Wistar rats, weighing 300-350 g, were divides into 4 groups such as control, MCAO (Middle cerebral artery occlusion) alone, MCAO plus sham laser acupuncture and MCAO plus laser acupuncture groups. Rats were subjected to control group were given a sham operation and received no treatment, while right middle cerebral artery occlusion (Rt. MCAO) was induced in rats were subjected to MCAO alone group with no treatment was given. Rats were subjected to either sham laser acupuncture or laser acupuncture, which was performed laser acupuncture 10 min once daily at Baihui (GV20) acupoint for 14 consecutive days after Rt. MCAO. The level of malondialdehyde (MDA) and antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD) in hippocampus were determined at the end of the experiment. The results showed that laser acupuncture at GV20 could decrease MDA level and increase the activity of CAT and SOD in hippocampus. However, the other possible underlying mechanisms are still required to explain actual actions of laser acupuncture treatment. |
