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Botulism |
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| รหัสดีโอไอ | |
| Creator | Jinatta Jittiwat |
| Title | Botulism |
| Contributor | - |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2559 |
| Journal Title | Isan Journal of Pharmaceutical Sciences |
| Journal Vol. | 12 |
| Journal No. | 2 |
| Page no. | 11-20 |
| Keyword | Botulinum toxin, SNARE complex, acetylcholine, neuromuscular junction, nicotinic acetylcholine receptor |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Botulism results from intoxication by botulinum toxin, which produced by a group of anaerobic spore forming organism called Clostidium botulinum. The spores of Clostidium botulinum are distributed widely in soil and water, which produces 8 types of toxin including type A, B, C1, C2, D, E, F and G. The toxin must enter the presynaptic terminal to cleave the SNARE complex, which including synaptobrevin, SNAP-25 and syntaxin. Each type of botulinum toxin is highly specific proteolytic cleavage of one of the proteins of SNARE complex, inhibits the release of acetylcholine (ACh) at neuromuscular junction (NMJ), leading to inhibition of synaptic transmission, leading to flaccid paralysis. Moreover, acetylcholine has an important role on parasympathetic nervous system; therefore the patient must be presented the signs and symptoms of cholinergic block as well. Moreover, injection of botulinum toxin type A have become one of the most popular for medical treatment such as myofascial pain, achalasia and cosmetic use in eldery. |
