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Techniques for Follicular Penetration Studies |
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| รหัสดีโอไอ | |
| Creator | 1. Worranan Rangsimawong 2. Tanasait Ngawhirunpat |
| Title | Techniques for Follicular Penetration Studies |
| Publisher | Faculty of Pharmaceutical Sciences KKU, MSU, UBU |
| Publication Year | 2558 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 11 |
| Journal No. | 2 |
| Page no. | 31-44 |
| Keyword | skin sandwich model,confocal laser scanning microscopy |
| ISSN | 19050852 |
| Abstract | Hair follicles were an interesting target structure for drug delivery system. Although the total amount of hair and its follicles were only 0.1% of the total skin surface, they represent important shunt routes into the skin for hydrophilic drug and high molecular weight biomolecules, as well as by particles-based drug delivery systems. Recently, many models have been developed for quantifi cation of the delivery of drug into hair follicles. This review focuses on differential stripping and selective blocking of hair follicles technique, skin sandwich technique, and novel optical imaging system. For differential stripping technique, a combination of tape stripping and cyanoacrylate biopsies have led to quantify drug deposition in the upper hair follicles and drug retention in hair follicles. |
