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Microneedle Techniques for DNA Transdermal Delivery |
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| รหัสดีโอไอ | |
| Creator | 1. Boonnada Pamornpathomkul 2. and Tanasait Ngawhirunpat |
| Title | Microneedle Techniques for DNA Transdermal Delivery |
| Publisher | Faculty of Pharmaceutical Sciences KKU, MSU, UBU |
| Publication Year | 2558 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 11 |
| Journal No. | 2 |
| Page no. | 16-30 |
| Keyword | microneedle,transdermal DNA delivery,skin,permeation |
| ISSN | 19050852 |
| Abstract | Currently, gene therapy has been the popular approach in the medical fi elds. Gene therapy relies on the use of DNA as a medicine involving the insertion of the therapeutic DNA into cells and tissue to treat a disease. Plasmid DNA based skin therapies are being tested and clinically developed for the treatment of genetic skin disorderssuch as, skin cancers, psoriasis and diabetic neuropathy. Moreover, a new approach to vaccination is currently being investigated with the concept of DNA vaccines. This new technology is interesting due to its advantages over the traditional vaccines. Skin is an optimal compartment for vaccine delivery, because of its high density of immunologic antigen-presenting cells residing both within the epidermis and dermis including Langerhans cells and dermal dendritic cells, respectively. Transdermal drug delivery offers an advantageous of drug administration and vaccine for prophylactic applications. |
