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Solid Dispersions: Technique to Enhance Solubilityof Poorly Water Soluble Drug |
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| รหัสดีโอไอ | |
| Creator | 1. Thisirak Woraphatphadung 2. Praneet Opanasopit |
| Title | Solid Dispersions: Technique to Enhance Solubilityof Poorly Water Soluble Drug |
| Publisher | Faculty of Pharmaceutical Sciences KKU, MSU, UBU |
| Publication Year | 2558 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 11 |
| Journal No. | 2 |
| Page no. | 1-15 |
| Keyword | solid dispersions,poorly water soluble drugs |
| ISSN | 19050852 |
| Abstract | Solid dispersions are one of the most promising strategies to enhance solubility of poorly water soluble drugs because they are easier to produce and more applicable. They show many advantages such as reducing particle size of drug, improving wettability and dissolvability, and converting crystalline structure of drug to amorphous form. The solid dispersions can also be classifi ed into three generations based on composition of formulation i.e. fi rst generation (using crystalline carriers: urea, mannitol), second generation (using amorphous carriers: polyvinylpyrrolidone, polyethylene glycol, hydroxypropyl methylcellulose) and third generation (using surfactant or amphiphilic polymer carriers: Gelucire?, Poloxamer?, Soluplus?). There are three different methods to prepare solid dispersions such as melting or fusion method, solvent evaporation method and melting-solvent method. |
