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A Feasibility Study of Alcoholic-Alkaline Treated Glutinous Rice Starch for Film Coating |
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| รหัสดีโอไอ | |
| Creator | Chiravut Pathumthanasup |
| Title | A Feasibility Study of Alcoholic-Alkaline Treated Glutinous Rice Starch for Film Coating |
| Contributor | Arom Tattawasart, Thaned Pongjanyakul, Padungkwan Chitropas |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2553 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 6 |
| Journal No. | 3 |
| Page no. | 91-103 |
| Keyword | Glutinous rice starch, alcoholic-alkaline treatment, film former, film coating |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | The objectives of this research were to study the properties of alcoholic-alkaline treated glutinous ricestarch (AGS) and to investigate the properties of AGS free film and AGS coated tablets using propranololhydrochloride as a model drug. The film forming properties of AGS were compared with those of hydroxypropylmethylcellulose E15LV (HPMC). The result showed that starch granule and gelatinization endotherm of AGSwas not appeared. This indicated that AGS was amorphous form, which was confirmed by powder XRD. Theswelling capacity and solubility of AGS in phosphate buffer pH 6.8 (PB 6.8) and 0.1 M HCl were higher thanthose in distilled water (PW). The solubility of AGS film in PB 6.8 and 0.1 M HCl, was not different, but higherthan that using PW. The moisture adsorption and moisture permeability of AGS film were similar to HPMC film.The moisture adsorption, disintegration time and T50% of the AGS coated tablets were similar to the HPMCcoated tablets. However, the AGS coated tablets showed rougher film surface than the HPMC coated tablets. Itcan be concluded that AGS can be used as a film former and it displayed strong feasibility for film coating oftablets. |
