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Enhanced Bromhexine Hydrochloride Solubility and Dissolution by Inclusion Complexation with Methylated ?-cyclodextrin |
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| รหัสดีโอไอ | |
| Creator | Nattha Kaewnopparat |
| Title | Enhanced Bromhexine Hydrochloride Solubility and Dissolution by Inclusion Complexation with Methylated ?-cyclodextrin |
| Contributor | Thitima Chuchom, Arunsri Sunthornpit, Amaravadee Jangwang, Sanae Kaewnopparat |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2552 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 5 |
| Journal No. | 2 |
| Page no. | 114-122 |
| Keyword | bromhexine hydrochloride, methylated ?-cyclodextrin, dissolution, solubility, inclusion complex |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | The aim of this study was to enhance the solubility and dissolution of bromhexine hydrochloride by inclusion complexation with the cyclodextrin derivative, methylated ?-cyclodextrin (M?CD). Inclusion complexes in 1:1 molar ratio were prepared by the kneading and coevaporation methods. The solubility of drug in methylated ?-cyclodextrin was studied. The complexes were characterized by differential scanning calorimetry (DSC), X-ray diffractometry, Fourier transform infrared (FT-IR) spectroscopy and dissolution studies. The solubility of bromhexine hydrochloride increased linearly with the concentration of methylated ?-cyclodextrin. The phase-solubility profile was classified as AL-type, indicating the formation of a 1:1 stoichiometric inclusion complex with an apparent stability constant (Ks) of 110 M??. The crystallinity of drug from inclusion complexes was reduced. The inclusion complex prepared by the coevaporation method showed interaction between drug and methylated ?-cyclodextrin. Both kneaded and coevaporated samples gave similar dissolution profiles; of 50-, and 5-fold increases in drug dissolution were observed within the first 5 mins compared to pure drug and physical mixtures, respectively. These inclusion complexes were effective in enhancing drug dissolution, with bromhexine hydrochloride completely dissolving within 10 mins. |
