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Caffeine Topical Gel Formulation |
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| รหัสดีโอไอ | |
| Creator | Thanaporn Amnualkit |
| Title | Caffeine Topical Gel Formulation |
| Contributor | Suthimaln Ingkatawornwong, Duangkhae Maneenuan, Kittichote Worachotekamjorn |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2551 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 4 |
| Journal No. | 1 |
| Page no. | 16-24 |
| Keyword | Caffeine gel, Carbopol, Propylene glycol |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | Caffeine was used topically as one of many ingredients in various cosmetic preparations for reducing under-eye puffiness and dark circles. Gels containing 3% w/w caffeine as an active ingredient were prepared in this study. Suitable co-solvent systems and gel-forming concentrations were studied. Their effects on caffeine release from formulation were also studied. Suitable gel formulations consisted of carbopol Ultrez-21 as a gel-forming agent and propylene glycol (PG) as a co-solvent. The result showed that the increased concentration of Carbopol Ultrez-21, affected the formulation and thereby giving higher viscosity. However, all concentrations Carbopol Ultrez-21 studied (0.2%, 0.5%, 1%, 2% and 4%) did not affect caffeine release significantly. The percentage of PG in the formulation greatly affected caffeine release. Formulation containing 15% and 30% w/w PG gave release rate from Higuchiโs equation of 2.47 ยฑ 0.26 mg/cmยฒ/hยฝ and 2.37 ยฑ 0.17 mg/cmยฒ/hยฝ, respectively which were lower when compared to release rate of 2.67 ยฑ 0.07 mg/cmยฒ/hยฝ from formulation containing 7.5% w/w PG. The best formulation of caffeine gel with good physical appearance and good release rate comprised of 3% caffeine, 0.5% carbopol Ultrez-21 and 7.5% PG. |
