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Preparation of Extemporaneously diazepam Suppositories: in Vitro Release and Aging Study |
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| รหัสดีโอไอ | |
| Creator | Nattha Kaewnopparat |
| Title | Preparation of Extemporaneously diazepam Suppositories: in Vitro Release and Aging Study |
| Contributor | Kwunchit Oungbho, Sanae Kaewnopparat, Theera Rittirod, Wipapom Rojanarat, Thanee Tessiri |
| Publisher | Faculty of Pharmaceutical Sciences KKU MSU UBU |
| Publication Year | 2549 |
| Journal Title | Isan Journal ofPharmaceutical Sciences |
| Journal Vol. | 2 |
| Journal No. | 1 |
| Page no. | 26-34 |
| Keyword | Suppositories, Diazepam Suppositories |
| URL Website | https://tci-thaijo.org/index.php/IJPS |
| Website title | Isan Journal ofPharmaceutical Sciences, IJPS |
| ISSN | 19050852 |
| Abstract | The objective of this study was to develop a fast-release extemporaneously diazepam suppository using pulverized diazepam tablet instead of diazepam powder. Four kinds of extemporaneously diazepam suppositories were formulated: 1) a conventional suppository with Witepsol H-15 as a base, 2) a conventional suppository with mixed polyethylene glycols (PEGs) as a base, 3) a hollow-type suppository with Witepsol H-15 as a base which contained pulverized diazepam in its cavity and 4) a hollow-type suppository with mixed PEGs as a base which contained pulverized diazepam in its cavity. The results of DSC thermograms indicated that diazepam was dissolved in Witepsol base and had strong affinity to this lipophilic base while diazepam dispersed in mixed PEGs base was still in the crystalline form. From the dissolution studies, the release of diazepam from suppository formulation no. 1, 3 and 4 was very slow. Diazepam suppository from formulation no. 2 exhibited the fastest release which complete dissolved after 30 minutes and gave the similar dissolution and permeation profiles compare to diazepam suppository using diazepam powder as the active ingredient. The content of diazepam from formulation no. 2 and the dissolution profiles after storage for 2 months did not significantly different from freshly prepared. Therefore, the extemporaneously diazepam conventional suppository which mixed PEGs as the base was found to be the most effective rapid-release formulation. |
