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Can the SNP on TCF19 and POU5F1 predict risk in allopurinol-induced severe cutaneous adverse drug reactions in Thai Patients? |
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| รหัสดีโอไอ | |
| Creator | Thawinee Jantararoungtong, Gaidganok Sornsamdang, Santirat Prommas, Napatrupron Koomdee, Apichaya Puangpetch, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Jettanong Klaewsongkram, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Chutika Srisuttiyakorn, Ticha Rerkpattanapipat, Chonlaphat Sukasem |
| Title | Can the SNP on TCF19 and POU5F1 predict risk in allopurinol-induced severe cutaneous adverse drug reactions in Thai Patients? |
| Contributor | Thawinee Jantararoungtong, Gaidganok Sornsamdang, Santirat Prommas, Napatrupron Koomdee, Apichaya Puangpetch, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Jettanong Klaewsongkram, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Chutika Srisuttiyakorn, Ticha Rerkpattanapipat, Chonlaphat Sukasem |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2563 |
| Journal Title | Genomics and Genetics |
| Journal Vol. | 13 |
| Journal No. | 2&3 |
| Page no. | 59-68 |
| Keyword | HLA-B*58:01, allopurinol, Thai, SCAR, CADR, drug hypersensitivity |
| URL Website | https://li01.tci-thaijo.org/index.php/gst/issue/view/16872 |
| Website title | https://li01.tci-thaijo.org/index.php/gst/article/view/154129 |
| ISSN | 24655198 |
| Abstract | The aim of this study was to investigate the association of Human leukocyte antigen B (HLA-B), Transcription Factor 19 (TCF19) and POU Class 5 Homeobox 1 (POU5F1) genes with allopurinol-induced cutaneous adverse drug reactions (CADR), including Stevens-Johnson syndrome/ toxic epidermal necrosis (SJS/TEN; n=21), drug rash with eosinophilia and systemic symptoms (DRESS; n=16) and maculopapular exanthema (MPE; n=7) in Thai patients. This case-control association study compares 44 cases with allopurinol-induced CADR with allopurinol-tolerant control patients (n=100), and a population control group (n=1,095). The control group comprised patients who had received allopurinol for more than 6 months without any adverse cutaneous event. HLA alleles were genotyped using a two-stage sequence-specific oligonucleotide probe system (PCR-SSOP). Variants in TCF19 (rs9263794 and rs1044870) and POU5F1 (rs9263796) were genotyped. The risk of allopurinol-induced CADR was significantly higher in the patients with HLA-B*58:01 allele with an odds ratio 240 (95%CI: 57.191007.08, p<0.0001). In addition, the single nucleotide polymorphisms (SNPs) were also significantly associated with the allopurinol-induced CADR (rs9263794; OR 57.20, p< 0.001, rs1044870; OR 77.31, p=0.003 and rs9263796; OR 84.14, p<0.0001). Furthermore, we found significant association between the SNPs and allopurinol-induced SJS/TEN, DRESS, and MPE (rs9263794; OR 304.4, p=0.0001, 31.7 p<0.0001, 18.3, p= 0.0011, rs1044870; OR 25.7, p=0.038, 124.4, p=0.0013, 258.4, p=0.0005 and rs9263796; OR 536.0, p<0.0001, 39.8, p<0.0001, 33.2, p=0.0001), respectively. |
