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The overexpressed antigens in triple negative breast cancer and application in immunotherapy |
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| รหัสดีโอไอ | |
| Creator | Niphat Jirapongwattana, Suyanee Thongchot, Chanitra Thuwajit |
| Title | The overexpressed antigens in triple negative breast cancer and application in immunotherapy |
| Contributor | Niphat Jirapongwattana, Suyanee Thongchot, Chanitra Thuwajit |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2563 |
| Journal Title | Genomics and Genetics |
| Journal Vol. | 13 |
| Journal No. | 1 |
| Page no. | 19-32 |
| Keyword | breast cancer, triple negative breast cancer, tumor-associated antigen, immunotherapy |
| URL Website | https://li01.tci-thaijo.org/index.php/gst/issue/view/16612 |
| Website title | https://li01.tci-thaijo.org/index.php/gst/article/view/242475 |
| ISSN | 24655198 |
| Abstract | Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) is considered a poor-prognosis subtype breast cancer with insensitivity to hormonal and targeted therapies. TNBC hasseveral overexpressed tumor-associated antigens (TAAs) that contribute to cancer progression and prognosis determination of the patients. Interestingly, the overexpressed TAAscan induce the host immune response which may provide an alternative potential treatment option for TNBC patients. In this review, four overexpressed antigens commonly reported in TNBC, their clinical significance,and current ongoing preclinical and clinical studies to target these antigens in immunotherapy including immunotoxin/drug-conjugated antibody, bispecific antibody, cancer vaccine and chimeric antigen receptor-T cells (CAR-T cells)are described. Theseimmunotherapy approaches using the overexpressed proteins as targets are proposed as important alternative treatmentsfor advanced TNBC patients. |
