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A report of schizophrenia in a patient with chromosome 3p26 deletion |
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| รหัสดีโอไอ | |
| Creator | Weerin Thammachote, Thanavadee Prachason, Nattinee Jantaratnotai, Ronnachai Kongsakon, Duangrurdee Wattanasirichaigoon, Natini Jinawath |
| Title | A report of schizophrenia in a patient with chromosome 3p26 deletion |
| Contributor | Weerin Thammachote, Thanavadee Prachason, Nattinee Jantaratnotai, Ronnachai Kongsakon, Duangrurdee Wattanasirichaigoon, Natini Jinawath |
| Publisher | Genetics Society of Thailand |
| Publication Year | 2563 |
| Journal Title | Genomics and Genetics |
| Journal Vol. | 13 |
| Journal No. | 1 |
| Page no. | 7-11 |
| Keyword | schizophrenia, CNV, SNP array, 3p26 microdeletion |
| URL Website | https://li01.tci-thaijo.org/index.php/gst/issue/view/16612 |
| Website title | https://li01.tci-thaijo.org/index.php/gst/article/view/240765 |
| ISSN | 24655198 |
| Abstract | A 41-year-old female patient presented at a psychiatric clinic at Ramathibodi Hospital. She was diagnosed as having schizophrenia 11 years ago (under the DSM-IV-TR criteria). She appeared to have poor insight and poor compliance. She had bothvisual and auditory hallucination. She also had suicidal thought, but never attempted because of embarrassment. The patient's past medical record and family history showed that she consumed1-2 bottles of alcohol per day. She has already been divorced twice. Her parents were also divorced. Other members in her family have no psychiatric history. Single nucleotide polymorphism (SNP) array revealed a 4.7-Mb deletion on the short arm of chromosome 3 within bands p26.1-3p26.3 encompassing CNTN4and CNTN6, which are genes associated with intellectual disability/developmental delay (ID/DD), growth retardation, and dysmorphic features. This deletion results in chromosome 3p26deletion syndrome and is linked to autism spectrum disorders (ASD). Multiple genes in the aberrant region play a role in synaptogenesis, synaptic transmission, and neurological development. Interestingly, chromosomal aberration in this region has not beenpreviouslyreportedto be associated with schizophrenia. This finding suggests that patients with 3p26 microdeletion have a potential to exhibit neuropsychiatric symptoms and that 3p26 might be a novel candidate locus for schizophrenia. |
