10.14456/gag.2016.10
Sex steroids regulate genes containing intragenic LINE-1 during menstrual cycles
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10.14456/gag.2016.10
Creator Saichon Chaiwongwatanakul, Viroj Boonyaratanakornkit, Sissades Thongsima, Apiwat Mutirangura, Pattamawadee Yanatatsaneejit
Title Sex steroids regulate genes containing intragenic LINE-1 during menstrual cycles
Publisher Genetics Society of Thailand
Publication Year 2559
Journal Title Genomics and Genetics
Journal Vol. 9
Journal No. 2&3
Page no. 72-77
Keyword estrogen, progesterone, menstrual phases, genes containing LINE-1
ISSN 24655198
Abstract Long interspersed element-1s (LINE-1s) are retrotransposable elements. Recent studies have shown that genes containing LINE-1s are regulated by epigenetic regulation of intragenic LINE-1s in cancer and in embryonic development. Moreover, intragenic LINE-1 may possess a regulatory function under physiological conditions. We hypothesized that female sex steroids could alter expressions of genes containing LINE-1. Here we analyzed the influence of intragenic LINE-1s on gene expression during menstrual phases by using expression array data from public database (Gene Expression Omnibus (GEO), (http://www.ncbi.nlm.nih.gov/geo). Gene expression levels in early, mid and late secretory phases were compared with those in the proliferative phase. Genes containing intragenic LINE-1s were highly and significantly up-regulated in early-secretory phase as compared to those in the proliferative phase in both GSE tests (GSE6364 with p< 1.05E-10; OR = 1.62; 95% CI = 1.40-1.88 and GSE4888 with p<2.22E-10; OR=1.61; 95% CI=1.39-1.87). Genes containing intragenic LINE-1 were significantly up-regulated in both mid- and late-secretory phase as compared to those in the proliferative phase (GSE4888 with p< 5.66E-03; OR=1.24; 95% CI = 1.06-1.44 and p<1.14E-04; OR=1.42; 95% CI=1.19-1.69). However, genes containing intragenic LINE-1 were found to be significantly down-regulated only in mid-secretory phase compared to those in the proliferative phase. (GSE6364 p<2.98E-02; OR=1.15; 95% CI=1.01-1.31 and GSE4888 p<6.22E-04; OR=1.25; 95% CI=1.10-1.41). Together, these data suggest that intragenic LINE-1 could play roles in regulation and expression of sex steroid regulated genes during menstrual cycles.
Genomics and Genetics

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