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Toxic Effects of Cyclophosphamide on Male Mice Fertility Development and Body Indicators |
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| รหัสดีโอไอ | |
| Creator | Heba Thakeb Yser |
| Title | Toxic Effects of Cyclophosphamide on Male Mice Fertility Development and Body Indicators |
| Publisher | Thai Society of Higher Education Institutes on Environment |
| Publication Year | 2566 |
| Journal Title | EnvironmentAsia |
| Journal Vol. | 16 |
| Journal No. | 3 |
| Page no. | 178-188 |
| Keyword | Cyclophosphamide, Mice fertility, Reproductive ability, Sperm abnormality, Sexual hormones |
| URL Website | http://www.tshe.org/ea/index.html |
| Website title | EnvironmentAsia |
| ISSN | 1906-1722 |
| Abstract | Chemotherapy is considered one of the crucial strategies for treating cancer. However, a variety of temporary and permanent side effects have been reported due to the use of these chemical compounds. The current study was designed to highlight the influence of cyclophosphamide (CYP) administration on reproductive development capability and fertility in male mice. Thirty pre-mature male mice were divided into three groups; (1) control groups (2) one group injected interperitoneally with 150 mg CYP, and (3) one group with 250 mg CYP. Injections were administered for four weeks. The results indicate a significant reduction in body and organs weights in treated groups when compared with the control group. Similarly, the reproductive capabilities were also decreased in a increasing trend. Zoospermia was detected in treated groups with CYP, and this reduction was more noticable in the 150 CYP group. Luteinizing hormone levels increased significantly in both treated groups while testosterone levels declined considerably in the CYP-treated groups. These findings imply the risks of using this drug in cancer remediation during the maturation period of mice fertility. More investigations are required to detect whether these CYP-associated consequences are reversible or permanent after treatment discontinuation. |
