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Protective Effect of Zizyphus spina christi-Leaves Extract against Amiodarone-Induced Hepato - and Nephrotoxicity in Male Albino Rats |
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| รหัสดีโอไอ | |
| Creator | Abdel-Aziz A. A. El-Sayed |
| Title | Protective Effect of Zizyphus spina christi-Leaves Extract against Amiodarone-Induced Hepato - and Nephrotoxicity in Male Albino Rats |
| Publisher | Thai Society of Higher Education Institutes on Environment |
| Publication Year | 2566 |
| Journal Title | EnvironmentAsia |
| Journal Vol. | 16 |
| Journal No. | 2 |
| Page no. | 87-98 |
| Keyword | Amiodarone, Cytokines, Hepatotoxicity, Nephrotoxicity, Zizyphus spina Christi |
| URL Website | http://www.tshe.org/ea/index.html |
| Website title | EnvironmentAsia |
| ISSN | 1906-1715 |
| Abstract | Amiodarone (AMD), an orally potent antidysrhythmic medication that has caused hepato-renaltoxicity on long-term administration, is commonly used across the world. Zizyphus spina christileaves extract have ameliorative effects (ZSC). This research elucidated the magnitude of thedamage to the liver and kidney tissues in AMD. Twenty four male albino rats were groupedinto three groups given daily doses by gastric tube for two weeks as follows; the 1st groupacted as a control group; the 2nd group received AMD; the 3rd group received AMD parallelto ZSC. Liver and kidney tissues prepared for histological examination and serum samplesscreened for biomarkers including; (I) liver injury enzymes: alanine aminotransferase (ALT),aspartate aminotransferase (AST) and alkaline phosphatase (ALP); (II) kidney injury indicators: urea, creatinine and albumin; and (III) inflammatory markers: interleukins (IL-1?, IL-1?, IL- 4, IL-6, IL-10, IFN-? and IFN-?). The findings showed that AMD caused hepatic and renal histological changes that included congestion of the blood vessels, leucocytic infiltration, dilated bile ducts and lymphatics and cytoplasmic vacuolation were observed. The biochemical findings showed an increase in the AMD group's ALT, AST, ALP, urea and creatinine levels in addition decrease in albumin concentration. The group of rats treated with AMD and ZSC, increased the improvements in liver and kidney histology, while the ALT, AST, ALP, urea and creatinine levels were reduced and albumin level increased and ameliorative the levels of inflammatory markers, interleukins. This finding collectively agreed that ZSC has a protective impact on AMD hepato-nephrotoxicity which can be due to its antioxidant properties. |
