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Cytomegalovirus Retinitis (CMVR) in HIV-infected Pediatric Patients in Chiang Mai University Hospital |
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| รหัสดีโอไอ | |
| Creator | 1. Dao Luewattananont 2. Somsanguan Ausayakhun 3. Peninnah Oberdorfer |
| Title | Cytomegalovirus Retinitis (CMVR) in HIV-infected Pediatric Patients in Chiang Mai University Hospital |
| Publisher | Faculty of Medicine |
| Publication Year | 2558 |
| Journal Title | Chiang Mai Medical Journal |
| Journal Vol. | 54 |
| Journal No. | 3 |
| Page no. | 121-127 |
| Keyword | Cytomegalovirus retinitis,pediatric,HIV |
| ISSN | 0125-5983 |
| Abstract | Background Cytomegalovirus retinitis (CMVR) is the most common opportunistic ocular infection in immunocompromised hosts. It afCMVR in Thai children.Objectives To describe the signs, symptoms, ocular manifestations, visual acuity, T-lymphocyte CD4 level, treatment, complications of treatment and time to progression of CMVR in human immunode? ciency virus (HIV)-infected pediatric patients in Chiang Mai University Hospital.Design Retrospective cohort studyMethod The records of 36 HIV-infected pediatric patients, who had ophthalmic examinations between January 2002 and December 2012, were reviewed.Results Of the 36 patients, 11 (14 eyes) had CMVR, 21 were normal and 4 (6 eyes) had other eye diseases. The average age (mean?SD) of the patients was 10.6?3.8 years and 9.5?3.6 years in the CMVR and normal group, respectively. The mean T-lymphocyte CD4 level was 23.7 cells/mm and 232.1 cells/mm in the CMVR and normal group, respectively. The mean log of minimum angle of resolution (MAR) in visual acuity was 1.27?1.1 and 0.11?0.1 in the CMVR and normal group, respectively. Patients receiving highly active antiretroviral therapy comprised 90.9% and 95% of the CMVR and normal group, respectively. Visual impairment was the most common presentation. Clinical manifestations showed opaci? cation of the retina with areas of hemorrhage, exudate and necrosis, periphlebitis, frosted branch angiitis and vitritis.Conclusions CMVR is associated with T-lymphocyte CD4 cells of <50 cells/mm . Visual impairment is the most common presentation. |
