|
Two Novel Spectrophotometric Methods for Determination of Naproxen via a Modulation to Hydroxy Analog |
|---|---|
| รหัสดีโอไอ | |
| Creator | Hana Sh.Mahmood |
| Title | Two Novel Spectrophotometric Methods for Determination of Naproxen via a Modulation to Hydroxy Analog |
| Contributor | Thura Z. Al-Sarraj |
| Publisher | King Mongkut's Institute of Technology Ladkrabang |
| Publication Year | 2563 |
| Journal Title | Current Applied Science and Technology |
| Journal Vol. | 20 |
| Journal No. | 2 |
| Page no. | 295-309 |
| Keyword | Naproxen, modulation, oxidation, potassium permanganate |
| URL Website | https://www.tci-thaijo.org/index.php/cast |
| Website title | https://www.tci-thaijo.org/index.php |
| ISSN | 2586-9396 |
| Abstract | Potassium permanganate was used for oxidation of the synthesized hydroxy analog of Naproxen by two methods. For the first method, the oxidation occurred in acidic medium, the excess of permanganate was followed at 545 nm. Beer's law is obeyed between concentrations of 10 ตg/10ml-80 ตg/10ml (1-8 ppm) with good sensitivity (molar absorptivity of 9.7x103l.mol-1.cm-1), good precision (RSD better than ฑ3.2 %) and high accuracy (relative error better than1.6%). Sandell's sensitivity index is 0.0237ตg.cm-2. The detection limit (LOD) is 0.075ตg/ml and the quantitation limit (LOQ) is 0.25ตg/ml. For the second method, potassium permanganate was used to oxidize the hydroxy analog of Naproxen in basic medium, and the manganate produced was followed at 610 nm. The linearity range was from 20 to 70 ตg/10ml (2-7 ppm) with good sensitivity (molar absorptivity of 6.8 x 103l.mol-1.cm-1), good precision (RSD better than ฑ2.5%) and high accuracy (relative error better than 1.51%). Sandell's sensitivity index is 0.0338ตg.cm-2 while the detection limit (LOD) is 0.0098ตg/ml and quantitation limit (LOQ) is 0.03296ตg/ml. The two methods were applied successfully for the determination of Naproxen after extraction of the active ingredient by ethyl acetate. |
