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Alteration of natural killer cell subset proportion is associated with risk factors of coronary artery disease in aging |
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| รหัสดีโอไอ | |
| Creator | Kanuengnit Srisak |
| Title | Alteration of natural killer cell subset proportion is associated with risk factors of coronary artery disease in aging |
| Contributor | Wisitsak Phoksawat, Nantarat Komanasin, Chanvit Leelayuwat, Amonrat Jumnainsong. |
| Publisher | Faculty of Associated Medical Sciences, Khon Kaen University, Thailand |
| Publication Year | 2563 |
| Journal Title | Archives of Allied Health Sciences |
| Journal Vol. | 32 |
| Journal No. | 2 |
| Page no. | 8-16 |
| Keyword | Immunosenescence, NK cell, Coronary artery disease, Chronic low-grade inflammation |
| URL Website | https://he01.tci-thaijo.org/index.php/ams/about |
| Website title | Archives of Allied Health Sciences (Arch AHS) |
| ISSN | 2730-1990 |
| Abstract | Currently, the world population is moving to aging society because of decreasing fertility rates and increasing survival in old age. In Thailand,the results of the National Statistics Office showed that the number and proportion of older people increase continuously. Age-related impairment of human immunity involves in many chronic inflammatory diseases such as coronary artery disease (CAD). Thus, age is one of the risk factors for CAD causing the chronic inflammation condition. Natural killer (NK) cell is one of the immune cells that change in aging. Thus, this study aims to investigate the alteration of NK cells and NK cell subsets in aging and their association with the risk factor of CAD. Bloodsamples from aging (โฅ 60 years old) group and who had any risk factors for CAD, were collected. Additionally, blood samples of young group (age < 35 years old) without risk factors associated with CAD were included. Whole blood from these samples were stained with anti-CD3 and anti-CD56 labeled with FITC and PerCP, respectively to determine NK cell subsets by flow cytometry technique. The result showed that the proportion of NK cell subsets (CD56bright/CD56dim) was significantly decreased in aging (p-value < 0.001) and also tended to decrease in aging who had more than or equal to 2 CAD risk factors when compared with aging who had less than 2 CAD risk factors (p-value = 0.051). Thus, this result suggested that alteration of NK cell subsets in aging was associated with the risk factor of CAD and this might be the marker for CAD that needs to be investigated further. |
